Reaktion #554630

Reaktionsgleichung

4-fluoro-3-(trifluoromethyl)benzoic acid

TMSCHN2

acetic acid

→

methyl 4-fluoro-3-(trifluoromethyl)benzoate

Lösungsmittel

MeOH

CH2Cl2

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGAfter the reaction was stirred for 10 min
2. 2
   EinengenThe mixture was concentrated

Vorschrift

A solution of 4-fluoro-3-(trifluoromethyl)benzoic acid (260 mg, 1.25 mmol, 1 eq) in MeOH (0.5 mL) and CH2Cl2 (2 mL) was treated with TMSCHN2 (2M in hexanes, 0.85 mL, 1.70 mmol, 1A eq) dropwise with stirring at room temperature. After the reaction was stirred for 10 min, acetic acid was added until the yellow color disappeared. The mixture was concentrated to afford methyl 4-fluoro-3-(trifluoromethyl)benzoate, which was used in the next step without further purification.

Quelle