Reaktion #554568

Reaktionsgleichung

H2O

Benzo[b]thiophene-2-ylboronic acid

9-chlorophenanthridin

sodium carbonate

→

9-Benzothienylphenanthridine

Ausbeute 78.0%

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturby refluxing under a N2 atmosphere for 5 hours
2. 2
   Extraktionthe mixture was extracted with chloroform
3. 3
   Trocknenby drying with sodium sulfate
4. 4
   FiltrationAfter filtration
5. 5
   Sonstigethe filtrate was evaporated to dryness under reduced pressure
6. 6
   SonstigeThe obtained solid was purified by column chromatography (eluent: chloroform) (amount: 1.15 g, yield: 78%)

Vorschrift

Benzo[b]thiophene-2-ylboronic acid (884 mg, 5.0 mmol) and 9-chlorophenanthridin (1.0 g, 4.8 mmol) were dissolved in tetrahydrofuran (30 ml), and palladium catalyst (160 mg, 0.14 mmol) and 2M sodium carbonate solution (20 ml) were added, followed by refluxing under a N2 atmosphere for 5 hours. The reaction solution was added to H2O and the mixture was extracted with chloroform, followed by drying with sodium sulfate. After filtration, the filtrate was evaporated to dryness under reduced pressure. The obtained solid was purified by column chromatography (eluent: chloroform) (amount: 1.15 g, yield: 78%).

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