Reaktion #55456

Reaktionsgleichung

2-(1-benzyl-5-methyl-4-imidazolyl)-1,3-dithian-5-one

sodium acetate

hydroxylamine hydrochloride

→

crude product

Ausbeute 94.4%

2-(1-Benzyl-5-methyl-4-imidazolyl)-1,3-dithian-5-one oxime

Ausbeute 94.4%

Lösungsmittel

chloroform

methanol

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed with water
2. 2
   Sonstigedried
3. 3
   Sonstigeevaporated

Vorschrift

To a solution of 2-(1-benzyl-5-methyl-4-imidazolyl)-1,3-dithian-5-one (11.2 g., 0.0368 mole) in methanol (50 ml.) and water (20 ml.) is added sodium acetate (3.1 g.) and hydroxylamine hydrochloride (2.6 g., 0.037 mole). The reaction is stirred at ambient temperature for 5 hours. The mixture is diluted with chloroform, washed with water, dried and evaporated to give a solid crude product (11.1 g.), 2-(1-benzyl-5-methyl-4-imidazolyl)-1,3-dithian-5-one oxime, which is used as is in the following steps.

Quelle