Reaktion #55446

Reaktionsgleichung

3,4-dibenzyloxyphenethylamine

p-chloroanilinoacetic acid

→

N-[2-(3,4-dibenzyloxyphenyl)ethyl]-2-(p-chloroanilino)acetamide

Ausbeute 50.4%

Lösungsmittel

benzene

Reaktionsbedingungen

Aufarbeitung

1. 1
   WaschenThe solution was washed with a diluted potassium carbonate aqueous solution
2. 2
   Sonstigedried
3. 3
   workup.DISTILLATIONThe solvent was distilled off from the benzene solution
4. 4
   Sonstigethe residue obtained
5. 5
   Sonstigewas purified by column chromatography on silica gel

Vorschrift

A mixture of 3,4-dibenzyloxyphenethylamine (36.2 g) and p-chloroanilinoacetic acid (20 g) was stirred for 3 hours at 190° C. The reaction mixture was dissolved in benzene. The solution was washed with a diluted potassium carbonate aqueous solution and dried. The solvent was distilled off from the benzene solution and the residue obtained was purified by column chromatography on silica gel to give N-[2-(3,4-dibenzyloxyphenyl)ethyl]-2-(p-chloroanilino)acetamide (27.2 g), mp 121° C.

Quelle