Reaktion #55365

Reaktionsgleichung

1-chlorocarbonyl-4-propionylpiperazine

piperazine

propionamide

→

1-propionylpiperazine hydrochloride

Lösungsmittel

xylene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigecan be prepared

Vorschrift

The 1-chlorocarbonyl-4-propionylpiperazine used as starting material can be prepared as follows. Anhydrous piperazine (120 g.) and propionamide (m.p. 80° C., 102 g.) in anhydrous xylene (100 cm3) are heated under reflux for 48 hours in the presence of iodine (0.9 g.) to give 1-propionylpiperazine hydrochloride (153.0 g.), m.p. 165° C. 1-Propionylpiperazine is liberated from its hydrochloride by the action of an excess of ammonia in diethyl ether. The ammonium chloride formed is separated by filtration and the 1-propionylpiperazine is isolated by evaporation of the ether.

Quelle