Reaktion #55351

Reaktionsgleichung

Phenyl chloroformate

2-(7-chloro-1,8-naphthyridin-2-yl)-3-hydroxy-isoindolin-1-one

→

2-(7-chloro-1,8-naphthyridin-2-yl)-3-phenoxycarbonyloxy-isoindolin-1-one

Ausbeute 80.7%

Lösungsmittel

pyridine

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeat about 25° C
2. 2
   SonstigeThe product which crystallises
3. 3
   Filtrationis filtered off
4. 4
   Waschenwashed with water (6×500 cc.)
5. 5
   SonstigeAfter drying

Vorschrift

Phenyl chloroformate (126 g.) is added to a suspension of 2-(7-chloro-1,8-naphthyridin-2-yl)-3-hydroxy-isoindolin-1-one (86.5 g.) in pyridine (980 cc.), whilst keeping the temperature at about 25° C. The reaction mixture is stirred for 3 hours at a temperature of about 20° C. and then poured into ice-water (9,000 cc.). The product which crystallises is filtered off, washed with water (6×500 cc.) and then with acetonitrile (3×200 cc.). After drying, 2-(7-chloro-1,8-naphthyridin-2-yl)-3-phenoxycarbonyloxy-isoindolin-1-one (96.7 g.), which melts at 235° C. with decomposition, is obtained.

Quelle