Reaktion #5535

Reaktionsgleichung

5-[2-(methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridine

hydrogen chloride methanol

→

desired product

Ausbeute 89.3%

5-[2-(methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridine.hydrochloride

Ausbeute 89.3%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.DISTILLATIONAfter the solvent was distilled off
2. 2
   Sonstigethe residue was crystallized from chloroform ether
3. 3
   SonstigeThen, the crystals thus obtained
4. 4
   Waschenwere washed with ether
5. 5
   Sonstigedried

Vorschrift

A suspension of 5-[2-(methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridine (543 g, 2 mmoles) in methanol (20 ml) was treated with hydrogen chloride-methanol. After the solvent was distilled off, the residue was crystallized from chloroform ether. Then, the crystals thus obtained were washed with ether and dried to obtain 550 mg of the desired product (89.3%, colorless crystals).

Quelle