Reaktion #55339

Reaktionsgleichung

2-(4-bromobutoxy)-2'-chlorobibenzyl

dimethylamine

→

2-(4-dimethylaminobutoxy)-2'-chlorobibenzyl hydrochloride

Ausbeute 93.0%

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe reaction mixture was concentrated and to the concentrate
2. 2
   workup.ADDITIONwas added 2N-NaOH solution
3. 3
   ExtraktionThe product was extracted with ether
4. 4
   Waschenwashed well with saturated sodium chloride solution
5. 5
   Trocknendried over anhydrous sodium sulfate
6. 6
   workup.ADDITIONTo the ether solution was added 20% ethanolic hydrogen chloride
7. 7
   Sonstigeto yield white crystals
8. 8
   SonstigeRecrystallization from ethanol-ether

Vorschrift

A solution of 3.0 g of 2-(4-bromobutoxy)-2'-chlorobibenzyl in 15 ml of 50% aqueous dimethylamine solution and 15 ml of tetrahydrofuran was stirred at room temperature for 5 hours. The reaction mixture was concentrated and to the concentrate was added 2N-NaOH solution. The product was extracted with ether, washed well with saturated sodium chloride solution and then dried over anhydrous sodium sulfate. To the ether solution was added 20% ethanolic hydrogen chloride to yield white crystals. Recrystallization from ethanol-ether gave 2.8 g (93% yield) of 2-(4-dimethylaminobutoxy)-2'-chlorobibenzyl hydrochloride, m. p. 122°-123° C.

Quelle