Reaktion #55337

Reaktionsgleichung

2-[4-(4-carboxypiperidino)butoxy]bibenzyl hydrochloride

thionyl chloride

ethanol

→

2-[4-(4-ethoxycarbonylpiperidino)butoxy]bibenzyl hydrochloride

Ausbeute 87.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturheated
2. 2
   Temperaturunder reflux for 30 minutes
3. 3
   Einengenconcentrated in vacuo
4. 4
   Sonstigerecrystallized from ethanolether

Vorschrift

To a solution of 3 g of 2-[4-(4-carboxypiperidino)butoxy]bibenzyl hydrochloride in 30 ml of ethanol was added dropwise 0.9 g of thionyl chloride. The reaction mixture was stirred for one hour, heated under reflux for 30 minutes, concentrated in vacuo and then recrystallized from ethanolether to give 2.8 g (87% yield) of 2-[4-(4-ethoxycarbonylpiperidino)butoxy]bibenzyl hydrochloride, m. p. 84°-87° C.

Quelle