Reaktion #5532

Reaktionsgleichung

5-[2-(amino)ethylthio]imidazo[1,2-a]pyridine.dihydrochloride

→

desired product

Ausbeute 99.7%

5-[2-(amino)ethylthio]imidazo[1,2-a]pyridine

Ausbeute 99.7%

Lösungsmittel

chloroform

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwas washed with 3N-sodium hydroxide (50 ml)
2. 2
   Extraktionthe aqueous layer was extracted with chloroform
3. 3
   Trocknenwas dried over anhydrous magnesium sulfate
4. 4
   workup.DISTILLATIONAfter the solvent was distilled off

Vorschrift

After a suspension of 5-[2-(amino)ethylthio]imidazo[1,2-a]pyridine.dihydrochloride (13.31 g, 50 mmoles) in chloroform (200 ml) was washed with 3N-sodium hydroxide (50 ml), the aqueous layer was extracted with chloroform, combined the chloroform layer was dried over anhydrous magnesium sulfate. After the solvent was distilled off to obtain 9.63 g of the desired product (99.7%, pale yellow oily product).

Quelle