Reaktion #55284

Reaktionsgleichung

3-carbethoxythiomorpholine

4-chlorophenyl isocyanate

→

3-carbethoxy-4-(4-chlorophenylaminocarbonyl)thiomorpholine

Ausbeute 30.5%

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeA mild exothermic reaction
2. 2
   workup.ADDITIONmixed
3. 3
   Filtrationthe precipitate was collected by filtration
4. 4
   Sonstigerecrystallized from a mixture of methylene chloride and ether

Vorschrift

Seven grams of 3-carbethoxythiomorpholine and 6.5 g of 4-chlorophenyl isocyanate were added to 60 ml of hexanes containing 10 drops of triethylamine as a catalyst. A mild exothermic reaction took place as the reactants mixed. After the mixture cooled to room temperature, the precipitate was collected by filtration and recrystallized from a mixture of methylene chloride and ether to give 4 g of 3-carbethoxy-4-(4-chlorophenylaminocarbonyl)thiomorpholine, mp 152.5°-154.5° C.

Quelle