Reaktion #5523

Reaktionsgleichung

(±)-6-acetyl-4-(di-n-propylamino)-1,2,2a,3,4,5-hexahydrobenz[cd]indole

triethylamine

2,2,2-trichloroethyl chloroformate

→

1-carbamylindoline

Lösungsmittel

CH2Cl2

Reaktionsbedingungen

Aufarbeitung

1. 1
   ExtraktionThe CH2Cl2 solution was extracted with water and 1N HCl
2. 2
   WaschenThe organic solution was washed with saturated NaHCO3 solution and with brine solution
3. 3
   TrocknenThe CH2Cl2 solution was dried (MgSO4)
4. 4
   Einengenconcentrated in vacuo

Vorschrift

To a solution of (±)-6-acetyl-4-(di-n-propylamino)-1,2,2a,3,4,5-hexahydrobenz[cd]indole (2.3 g, 7.7 mmol) and triethylamine (1.1 ml, 8 mmol) in 90 ml CH2Cl2 under N2 was added dropwise a solution of 2,2,2-trichloroethyl chloroformate. The reaction mixture was stirred at RT for 1 hr. The CH2Cl2 solution was extracted with water and 1N HCl. The organic solution was washed with saturated NaHCO3 solution and with brine solution. The CH2Cl2 solution was dried (MgSO4) and concentrated in vacuo to give 3.3 g of the 1-carbamylindoline.

Quelle