Reaktion #55217

Reaktionsgleichung

3-(2',4'-difluoro-4-biphenylyl)-3-oxopropionic acid ethyl ester

ethyl acetate

→

3-(2',4'-difluoro-4-biphenylyl)butyric acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.DISSOLUTIONis dissolved in 25 ml
2. 2
   Sonstigeof platinum at 20° and under 1 atmosphere until the absorption of hydrogen
3. 3
   FiltrationThe mixture is filtered
4. 4
   Sonstigethe filtrate is evaporated

Vorschrift

1 g. of 3-(2',4'-difluoro-4-biphenylyl)-3-butenoic acid, obtained by reacting 3-(2',4'-difluoro-4-biphenylyl)-3-oxopropionic acid ethyl ester with triphenylphosphinemethylene and saponifying the reaction product, is dissolved in 25 ml. of ethyl acetate and hydrogenated on 0.1 g. of platinum at 20° and under 1 atmosphere until the absorption of hydrogen has ceased. The mixture is filtered and the filtrate is evaporated to give 3-(2',4'-difluoro-4-biphenylyl)butyric acid, m.p. 109°-110°.

Quelle