Reaktion #552169

Reaktionsgleichung

1-(phenylmethyl)-N-(2,2,2-trifluoroethyl)-3-pyrrolidinemethanamine

hydrogen

→

N-(2,2,2-trifluoroethyl)-3-pyrrolidinemethanamine

Ausbeute 53.2%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe catalyst was filtered
2. 2
   Sonstigethe filtrate evaporated under reduced pressure
3. 3
   workup.DISTILLATIONThe residue was distilled under vacuum (63°-65° C., 2.8 mm Hg)

Vorschrift

A mixture of 7.15 g (26.3 mmole) 1-(phenylmethyl)-N-(2,2,2-trifluoroethyl)-3-pyrrolidinemethanamine 100 ml of methanol and 0.7 g of 20% palladium on carbon was shaken in an atmosphere of hydrogen at about 4.5×105Pa and at room temperature for 24 hours. The catalyst was filtered and the filtrate evaporated under reduced pressure. The residue was distilled under vacuum (63°-65° C., 2.8 mm Hg) to give 2.55 g of N-(2,2,2-trifluoroethyl)-3-pyrrolidinemethanamine.

Quelle