Reaktion #55208

Reaktionsgleichung

HCl

4-(1-bromoethyl)-2',4'-difluorobiphenyl

ethyl acetoacetate

KOH

→

3-(2',4'-difluoro-4-biphenylyl)butyric acid

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture is cooled
2. 2
   WaschenThe reaction mixture is washed with ether

Vorschrift

1 g. of 2-[1-(2',4'-difluoro-4-biphenylyl)ethyl]-butan-3-one acid ethyl ester, obtained by reacting 4-(1-bromoethyl)-2',4'-difluorobiphenyl with ethyl acetoacetate, and 15 ml. of 50% KOH are stirred for 45 minutes at 90° under N2. The mixture is cooled, diluted with water and brought to pH 10 with HCl. The reaction mixture is washed with ether and worked up in the customary manner to give 3-(2',4'-difluoro-4-biphenylyl)butyric acid, m.p. 109°-110°.

Quelle