Reaktion #55207

Reaktionsgleichung

3-(2',4'-difluoro-4-biphenylyl)butyric acid

acetone

→

3-(2',4'-difluoro-4-biphenylyl)-3-hydroxybutyric acid

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.DISSOLUTIONare dissolved in a mixture of 15 ml
2. 2
   Temperaturthe mixture is warmed to 45° for 4 hours

Vorschrift

3.55 g. of 3-(2',4'-difluoro-4-biphenylyl)-3-bromobutyric acid, obtained by brominating 3-(2',4'-difluoro-4-biphenylyl)butyric acid, are dissolved in a mixture of 15 ml. of acetone and 15 ml. of water. One drop of sulfuric acid is added and the mixture is warmed to 45° for 4 hours and worked up in the customary manner to give 3-(2',4'-difluoro-4-biphenylyl)-3-hydroxybutyric acid, m.p. 121°-123°.

Quelle