Reaktion #55206

Reaktionsgleichung

1 -hydroxy-3-butanone

sulfuric acid

magnesium

4-bromo-2',4'-difluorobiphenyl

→

3-(2',4'-difluoro-4-biphenylyl)butane-1,3-diol

Lösungsmittel

ether

ether

ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeobtained from 2.69 g
2. 2
   workup.STIRRINGThe mixture is stirred for two hours more

Vorschrift

0.44 g. of 1 -hydroxy-3-butanone in 40 ml. of ether is added dropwise, at 20° to stirred Grignard solution obtained from 2.69 g. of 4-bromo-2',4'-difluorobiphenyl and 0.24 g. of magnesium in 100 ml. of ether. The mixture is stirred for two hours more and the resulting alcoholate is decomposed with dilute sulfuric acid. The ether phase is worked up in the customary manner to give 3-(2',4'-difluoro-4-biphenylyl)butane-1,3-diol, m.p. 82°-84°.

Quelle