Reaktion #55107

Reaktionsgleichung

Sodium

propane-1,3-diol

4-chloromethylimidazole hydrochloride

→

4-(3-hydroxypropoxy)methylimidazole

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturSubsequent heating at 60°-65° for 3 hours
2. 2
   Temperaturcooling
3. 3
   Filtrationfiltration and concentration

Vorschrift

Sodium (13.5 g.) was added over 3 hours to propane-1,3-diol (450 ml.) under nitrogen at 70° with stirring. This solution was added over 20 minutes to a stirred solution of 4-chloromethylimidazole hydrochloride (50.0 g.) under nitrogen at 40°-60°. Subsequent heating at 60°-65° for 3 hours followed by overnight cooling, filtration and concentration gave 4-(3-hydroxypropoxy)methylimidazole. Subsequent reaction with thionyl chloride gave 4-(3-chloropropoxy)methylimidazole hydrochloride (38.3 g.).

Quelle