Reaktion #550880

Reaktionsgleichung

1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-methyl-1-piperazinyl)quinoline-3-carboxylic acid

ethyl iodide

triethylamine

→

1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-ethyl-3-methyl-1-piperazinyl)quinoline-3-carboxylic acid hydriodide monohydrate

Ausbeute 46.2%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solution is evaporated in vacuo
2. 2
   Sonstigethe undissolved product is recrystallised from methanol

Vorschrift

A mixture of 1.7 g (0.005 mol) of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-methyl-1-piperazinyl)quinoline-3-carboxylic acid, 1.7 g (0.011 mol) of ethyl iodide and 1.1 g of triethylamine in 20 ml of DMF is heated at 80° C. for 3 hours. The solution is evaporated in vacuo, the crystalline residue is stirred thoroughly with 10 ml of water and the undissolved product is recrystallised from methanol. 0.6 g (32% of theory) of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-ethyl-3-methyl-1-piperazinyl)quinoline-3-carboxylic acid hydriodide monohydrate, with a decomposition point of 285°-288° C., is obtained.

Quelle