Reaktion #55037

Reaktionsgleichung

1-iodopropane

N-(4-chlorophenyl)-N-(4-piperidinyl)benzeneacetamide

N,N-dimethylethanamine

1-iodopropane

→

N-(4-chlorophenyl)-N-(1-propyl-4-piperidinyl)benzeneacetamide hydrochloride

Lösungsmittel

benzene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturrefluxed for 47 hours
2. 2
   workup.STIRRINGstirring
3. 3
   Temperaturrefluxing
4. 4
   TemperaturThe reaction mixture is cooled
5. 5
   Filtrationfiltered
6. 6
   WaschenThe filtrate is washed with water
7. 7
   Sonstigedried
8. 8
   Sonstigeevaporated in vacuo
9. 9
   FiltrationThe precipitated solid salt is filtered off
10. 10
    Sonstigedried

Vorschrift

To a stirred solution of 4 parts of N-(4-chlorophenyl)-N-(4-piperidinyl)benzeneacetamide and 3 parts of N,N-dimethylethanamine in 200 parts of benzene are added portionwise 4 parts of 1-iodopropane and the whole is stirred and refluxed for 47 hours. Then the second portion of 4 parts of 1-iodopropane is added and stirring and refluxing is continued for another 20h.20. The reaction mixture is cooled and filtered. The filtrate is washed with water, dried and evaporated in vacuo. From the oily free base, the hydrochloride salt is prepared in the conventional manner in 1,1'-oxybisethane. The precipitated solid salt is filtered off and dried, yielding 3.5 parts of N-(4-chlorophenyl)-N-(1-propyl-4-piperidinyl)benzeneacetamide hydrochloride; mp. 235.5° C.

Quelle