Reaktion #55028

Reaktionsgleichung

potassium iodide

1-iodopropane

N-(2,6-dimethylphenyl)-4-piperidinamine

sodium carbonate

→

N-(2,6-dimethylphenyl)-1-propyl-4-piperidinamine

Lösungsmittel

benzene

benzene

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONAfter the addition
2. 2
   workup.STIRRINGstirring
3. 3
   Temperaturat reflux temperature
4. 4
   TemperaturThe reaction mixture is cooled
5. 5
   SonstigeThe organic layer is separated
6. 6
   Sonstigedried
7. 7
   Sonstigeevaporated in vacuo
8. 8
   workup.DISTILLATIONThe oily residue is distilled

Vorschrift

To a warm (about 40° C.) and stirred mixture of 5 parts of N-(2,6-dimethylphenyl)-4-piperidinamine, 5 parts of sodium carbonate, a few crystals of potassium iodide in 120 parts of benzene is added dropwise a solution of 5.1 parts of 1-iodopropane in 80 parts of benzene. After the addition is complete, stirring is continued for 40 hours at reflux temperature. The reaction mixture is cooled and 50 parts of water are added. The organic layer is separated, dried and evaporated in vacuo. The oily residue is distilled, yielding 10.2 parts of N-(2,6-dimethylphenyl)-1-propyl-4-piperidinamine; bp. 135° C. at 0.2 mm. pressure.

Quelle