Reaktion #55001

ord-c1e13b2844ad4e0197ffac33f9b44843

Reaktionsgleichung

NCCCN
1,3-Diaminopropane
CSC(N)=[NH+]CCSCc1nc[nH]c1C.CSC(N)=[NH+]CCSCc1nc[nH]c1C.O=S(=O)([O-])[O-]
S-methyl-N-[2-((5-methyl-4-imidazolyl)methylthio)ethyl]thiouronium sulphate
→
Cc1[nH]cnc1CSCCN=C(N)NCCCNC(N)=NCCSCc1nc[nH]c1C
title compound
Cc1[nH]cnc1CSCCN=C(N)NCCCNC(N)=NCCSCc1nc[nH]c1C
1,3-bis-[N'-(2-(5-Methyl-4-imidazolylmethylthio)ethyl)guanidino]propane

Edukte

NCCCN
1,3-Diaminopropane
CSC(N)=[NH+]CCSCc1nc[nH]c1C.CSC(N)=[NH+]CCSCc1nc[nH]c1C.O=S(=O)([O-])[O-]
S-methyl-N-[2-((5-methyl-4-imidazolyl)methylthio)ethyl]thiouronium sulphate

Reagenzien

Keine

Lösungsmittel

O
water

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Temperaturthe mixture was heated
  2. 2
    Temperaturunder reflux for 2 hours
  3. 3
    Einengenconcentration the residue
  4. 4
    SonstigeRecrystallisation from ethanol

Vorschrift

1,3-Diaminopropane (0.37 g) was added to a solution of S-methyl-N-[2-((5-methyl-4-imidazolyl)methylthio)ethyl]thiouronium sulphate (2.93g) in water (10 ml) and the mixture was heated under reflux for 2 hours. Following concentration the residue was converted into the picrate with an aqueous solution of sodium picrate. Recrystallisation from ethanol afforded the title compound as the dipicrate (1.1 g) m.p. 114°-6°.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04151289uspto-grants-1979_04