Reaktion #549548

Reaktionsgleichung

3-tert.-butyl-5-amino-1H-pyrazole

2,6-dimethoxybenzoyl chloride

→

N-[3-(1,1-dimethylethyl)-1H-pyrazol-5-yl]-2,6-dimethoxybenzamide

Ausbeute 18.2%

Lösungsmittel

benzene

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction mixture was heated
2. 2
   Temperaturat reflux for sixteen hours
3. 3
   TemperaturThe reaction mixture was then cooled
4. 4
   Filtrationfiltered
5. 5
   Sonstigethe solvent was removed from the filtrate by evaporation
6. 6
   SonstigeThe residue was crystallized from ethyl acetate

Vorschrift

To a stirred solution of 1.39 g of 3-tert.-butyl-5-amino-1H-pyrazole in 50 ml of benzene were added in one portion 2.01 g of 2,6-dimethoxybenzoyl chloride. The reaction mixture was heated at reflux for sixteen hours. The reaction mixture was then cooled, filtered, and the solvent was removed from the filtrate by evaporation. The residue was crystallized from ethyl acetate to provide 550 mg of N-[3-(1,1-dimethylethyl)-1H-pyrazol-5-yl]-2,6-dimethoxybenzamide.

Quelle