Reaktion #54919

Reaktionsgleichung

2-benzoyl-4-chlorophenylisothiocyanate

methyl hydrazine

isothiocyanate

→

N-(2-benzoyl-4-chlorophenyl)-methyl-hydrazinecarbothioamide

Ausbeute 91.0%

Lösungsmittel

ethyl ether

ethyl ether

ethyl ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooled in an ice bath
2. 2
   workup.STIRRINGthe reaction mixture was stirred at room temperature for about 30 minutes
3. 3
   SonstigeThe solid was collected
4. 4
   Waschenwashed with additional ethyl ether

Vorschrift

A solution of 5.48 grams (0.02 mole) of 2-benzoyl-4-chlorophenylisothiocyanate in about 50 ml of ethyl ether was added dropwise to a solution containing 1.5 ml (0.028 mole) of methyl hydrazine (98%) in about 50 ml of ethyl ether cooled in an ice bath. Additional ethyl ether was added to facilitate stirring. Following addition of the isothiocyanate, the reaction mixture was stirred at room temperature for about 30 minutes. The solid was collected and washed with additional ethyl ether to yield 5.82 grams (91% yield) of N-(2-benzoyl-4-chlorophenyl)-methyl-hydrazinecarbothioamide as a white solid. The melting point was found to be 168.5°-170° C.

Quelle