Reaktion #54882

Reaktionsgleichung

4-[4-Acetyl-7-(1-hydroxycyclohexyl)-6-heptyn-1-yl]benzoic acid

hydrogen

→

title compound

4-[4-Acetyl-7-(1-hydroxycyclohexyl)heptyl]benzoic Acid

Lösungsmittel

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeat 1 atmosphere pressure and room temperature
2. 2
   FiltrationThe catalyst is filtered off
3. 3
   Sonstigethe solvent is evaporated
4. 4
   Sonstigethe residue (5 g.) is chromatographed on 75 g

Vorschrift

4-[4-Acetyl-7-(1-hydroxycyclohexyl)-6-heptyn-1-yl]benzoic acid (5.1 g., 0.014 mole) in ethyl acetate (55 ml.) is hydrogenated over 2.0 g. of a 5% Pt on charcoal catalyst at 1 atmosphere pressure and room temperature. The theoretical amount of hydrogen (0.028 mole) is absorbed in 25 minutes. The catalyst is filtered off, the solvent is evaporated and the residue (5 g.) is chromatographed on 75 g. of silica gel with 2% methanol in chloroform as eluant. The title compound is obtained as a colorless viscous oil.

Quelle