Reaktion #5488

Reaktionsgleichung

Cis ethyl 3-bromo-2-oxo-1-azacyclodecane-10-carboxylate

→

cis ethyl 3-acetoxy-2-oxo-1-azacyclodecane-10-carboxylate

Lösungsmittel

dimethylformamide

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooling back to room temperature
2. 2
   Filtrationfiltered through a pad of silica gel
3. 3
   Sonstigethe solvent is evaporated

Vorschrift

Cis ethyl 3-bromo-2-oxo-1-azacyclodecane-10-carboxylate (2.96 g, 9.67 mmol) is dissolved in dimethylformamide (30 mL). Silver acetate (6.35 g, 38 mmol) is added, and the reaction is heated to 100° C. for 3 hours. After cooling back to room temperature, the reaction is diluted with ethyl acetate (100 mL), filtered through a pad of silica gel, and the solvent is evaporated to give crude cis ethyl 3-acetoxy-2-oxo-1-azacyclodecane-10-carboxylate.

Quelle