Reaktion #548472

Reaktionsgleichung

phthalic anhydride

2-amino-2,3-dimethylbutyronitrile

→

N-(1-cyano-1,2-dimethylpropyl)phthalamic acid

Ausbeute 90.0%

Lösungsmittel

methylene chloride

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONAfter the addition
2. 2
   Temperaturheating
3. 3
   TemperaturThe mixture is cooled
4. 4
   Sonstigethe precipitate removed by filtration
5. 5
   Waschenwashed with methylene chloride
6. 6
   Sonstigeair-dried

Vorschrift

To a stirred boiling mixture of 28.1 g (0.189 mole) of phthalic anhydride in 28 ml methylene chloride is added dropwise 23.6 g (0.21 mole) of 2-amino-2,3-dimethylbutyronitrile in 57 ml methylene chloride. After the addition, heating is continued for 3 hours. The mixture is cooled and the precipitate removed by filtration, washed with methylene chloride and air-dried to give 44.2 g (90%) of N-(1-cyano-1,2-dimethylpropyl)phthalamic acid, melting point 154°-155° C.

Quelle