Reaktion #54844

Reaktionsgleichung

3-chloro-4-cyclohexylphenylpropiolic acid

quinoline

→

3-chloro-4-cyclohexylethynylbenzene

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed thoroughly with dilute hydrochloric acid
2. 2
   Waschenby washing with sodium bicarbonate (10%)
3. 3
   Wascheneluted with N-hexane
4. 4
   Sonstigeto give a fraction
5. 5
   Sonstigefree of carbonyl absorption (I.R.)
6. 6
   SonstigeRemoval of solvent

Vorschrift

3-chloro-4-cyclohexylphenylpropiolic acid (7.3 g.) is heated at 120°-124° for 5 hours in quinoline. The reaction product is diluted with water and washed thoroughly with dilute hydrochloric acid. This is followed by washing with sodium bicarbonate (10%). The material is passed through a short aluminum (H+) column, eluted with N-hexane to give a fraction free of carbonyl absorption (I.R.). Removal of solvent gives 3-chloro-4-cyclohexylethynylbenzene.

Quelle