Reaktion #54826

Reaktionsgleichung

hydrogen

hydrogen

ethyl 3-nitro-4-cyclohexylphenylglyoxylate

methanol

→

ethyl 3-amino-4-cyclohexylphenylglyoxylate

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONA mixture of 15.3 g
2. 2
   Sonstigeare absorbed
3. 3
   FiltrationThe mixture is filtered
4. 4
   Waschenwashed with methanol
5. 5
   Einengenthe filtrate concentrated in vacuo

Vorschrift

A mixture of 15.3 g. (0.05 moles) of ethyl 3-nitro-4-cyclohexylphenylglyoxylate in 100 ml. methanol containing 0.05 mole citric acid and 1.5 g. of 5% palladium-on-carbon is shaken with hydrogen at 3 atm. pressure and 27° C. until 3 moles of hydrogen are absorbed. The mixture is filtered, washed with methanol and the filtrate concentrated in vacuo to obtain ethyl 3-amino-4-cyclohexylphenylglyoxylate, isolated as the citrate salt.

Quelle