Reaktion #54825

Reaktionsgleichung

trifluoromethyl iodide

ethyl 3-bromo-4-cyclohexylphenylglyoxylate

→

ethyl 3-trifluoromethyl-4-cyclohexylphenylglyoxylate

Lösungsmittel

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooled
2. 2
   Filtrationfiltered
3. 3
   Sonstigeevaporated in vacuo
4. 4
   workup.ADDITIONof water is added to the residue
5. 5
   Extraktionextracted with ether
6. 6
   ExtraktionThe ether extract
7. 7
   Sonstigeis dried
8. 8
   Sonstigeevaporated to dryness
9. 9
   workup.DISTILLATIONdistilled

Vorschrift

To a solution of 0.01 moles of ethyl 3-bromo-4-cyclohexylphenylglyoxylate in 50 ml. of dimethylformamide is added 0.15 moles of trifluoromethyl iodide and 0.02 g. of copper powder. The reaction is shaken in a sealed tube for 5 hours at 140° C., cooled, and then filtered and evaporated in vacuo. 200 ml. of water is added to the residue and extracted with ether. The ether extract is dried, evaporated to dryness and distilled to obtain ethyl 3-trifluoromethyl-4-cyclohexylphenylglyoxylate.

Quelle