Reaktion #54817

Reaktionsgleichung

Methyl 1-naphthyl ketone

chloroform

hydrogen bromide

→

bromomethyl 1-naphthyl ketone

Lösungsmittel

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONis treated with 26.5 g
2. 2
   SonstigeThe resulting reaction mixture
3. 3
   Temperaturis heated
4. 4
   Temperaturunder reflux
5. 5
   Sonstigeis removed
6. 6
   workup.ADDITIONether is added
7. 7
   Sonstigethe copper (I) bromide is removed by filtration
8. 8
   SonstigeEvaporation of the filtrate under reduced pressure

Vorschrift

Methyl 1-naphthyl ketone (10.1 g.), in 50 ml of a 1:1 mixture of chloroform and ethyl acetate is treated with 26.5 g. of copper (II) bromide. The resulting reaction mixture is heated under reflux with vigorous stirring until the evolution of hydrogen bromide ceases. When the reaction is complete the solvent is removed, ether is added and the copper (I) bromide is removed by filtration. Evaporation of the filtrate under reduced pressure yields crude bromomethyl 1-naphthyl ketone.

Quelle