Reaktion #5481

Reaktionsgleichung

n-butyllithium hexane

1-azabicyclo[3.3.1]nonane-5-methanol

4-amino-5-chloro-2-methoxybenzoic acid

1,1'-carbonyldiimidazole

→

pale yellow solid

Ausbeute 57.3%

4-Amino-5-chloro-2-methoxybenzoic acid 1-azabicyclo[3.3.1]non-5-ylmethyl ester

Ausbeute 57.3%

Lösungsmittel

tetrahydrofuran

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigedegassed with a stream of nitrogen over 10 minutes
2. 2
   workup.STIRRINGstirred for 30 minutes
3. 3
   Einengenconcentrated in vacuo
4. 4
   SonstigeThe above prepared suspension
5. 5
   workup.STIRRINGthe mixture was stirred overnight (18 hours)
6. 6
   Einengenconcentrated in vacuo
7. 7
   SonstigeThe residue was partitioned between methylene chloride (100 mL)
8. 8
   workup.ADDITIONcontaining a little 2-propanol and saturated aqueous sodium carbonate (50 mL)
9. 9
   Sonstigethe organic layer was separated
10. 10
    ExtraktionThe aqueous solution was extracted with methylene chloride (2×50 mL)
11. 11
    Trocknenthe combined organic solution was dried (Na2SO4)
12. 12
    Einengenconcentrated in vacuo
13. 13
    Sonstigerecrystallized from acetonitrile (2 crops)

Vorschrift

A solution of 4-amino-5-chloro-2-methoxybenzoic acid (2.02 g, 10 mmol) in anhydrous tetrahydrofuran (10 mL) under nitrogen was treated with 1,1'-carbonyldiimidazole (1.70 g, 10.5 mmol), stirred for one hour, then degassed with a stream of nitrogen over 10 minutes. Meanwhile, a cooled (-10° C.) solution of 1-azabicyclo[3.3.1]nonane-5-methanol (1.71 g, 11 mmol) in anhydrous tetrahydrofuran (10 mL) under nitrogen was treated (via syringe) with 2.5N n-butyllithium/hexane (10.7 mmol), stirred for 30 minutes, concentrated in vacuo, and taken up in anhydrous tetrahydrofuran (10 mL) under nitrogen. The above prepared suspension was transferred into this solution, and the mixture was stirred overnight (18 hours) and concentrated in vacuo. The residue was partitioned between methylene chloride (100 mL) containing a little 2-propanol and saturated aqueous sodium carbonate (50 mL), and the organic layer was separated. The aqueous solution was extracted with methylene chloride (2×50 mL), and the combined organic solution was dried (Na2SO4), concentrated in vacuo and recrystallized from acetonitrile (2 crops) to afford 1.94 g (57%) of pale yellow solid; mp 152.5°-154.5° C.

Quelle