Reaktion #547778

Reaktionsgleichung

potassium hydroxide

Salicylaldehyde

2-methylthiazole

hydrochloric acid

→

title compound

Ausbeute 39.5%

2-(2′-hydroxystyryl)benzothiazole

Ausbeute 39.5%

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction mixture was cooled
2. 2
   WaschenThe aqueous layer was washed with ether
3. 3
   Extraktionextracted again with ethyl acetate
4. 4
   SonstigeThe organic solvent was dried
5. 5
   Einengenconcentrated

Vorschrift

Salicylaldehyde (6.1 g) and 2-methylthiazole (7.5 g) were mixed and conc. hydrochloric acid (1.5 ml) was added thereto. The mixture was stirred with heating at 100° C. for 9 hr. The reaction mixture was cooled, and aqueous potassium hydroxide solution was added. The aqueous layer was washed with ether and made acidic with hydrochloric acid and extracted again with ethyl acetate. The organic solvent was dried and concentrated to give the title compound (2.5 g) as pale-yellow crystals, melting point 235–236° C.

Quelle