Reaktion #54719

Reaktionsgleichung

dimethyl 6-chloro-2,4-pyrimidine-dicarbamate-3-oxide

1,2,5,6-tetrahydropyridine

→

dimethyl 6-[3,6-dihydro-1(2H)-pyridyl]-2,4-pyrimidine-dicarbamate-3-oxide

Lösungsmittel

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONA suspension of 10 g
2. 2
   FiltrationThe resulting precipitate is filtered off
3. 3
   Sonstigerecrystallized from a mixture of methylene chloride and methanol, there

Vorschrift

A suspension of 10 g. of dimethyl 6-chloro-2,4-pyrimidine-dicarbamate-3-oxide in 40 ml. of methylene chloride is treated with 20 ml. of 1,2,5,6-tetrahydropyridine and stirred at room temperature under an argon atmosphere for 16 hours. The resulting precipitate is filtered off and recrystallized from a mixture of methylene chloride and methanol, there being obtained pure dimethyl 6-[3,6-dihydro-1(2H)-pyridyl]-2,4-pyrimidine-dicarbamate-3-oxide, having a melting point of 203° C.

Quelle