Reaktion #54696

Reaktionsgleichung

1,2,3,4,10,10a-hexahydro-5phenylbenz[g]isoquinoline

sodium carbonate

sodium iodide

isopropylbromide

→

1,2,3,4,10,10a-Hexahydro-2-isopropyl-5-phenylbenz[g]isoquinoline

Lösungsmittel

dimethylformamide

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeare preheated to 50°
2. 2
   Temperaturcooled
3. 3
   workup.ADDITIONpoured onto ice/water
4. 4
   ExtraktionThe organic substance is extracted with benzene
5. 5
   Waschenthe extracts washed with water
6. 6
   Trocknendried over sodium sulphate
7. 7
   Sonstigeevaporated

Vorschrift

A mixture of 22.0 g of 1,2,3,4,10,10a-hexahydro-5phenylbenz[g]isoquinoline, 20.0 g of sodium carbonate and 0.2 g of sodium iodide in 180 ml of dimethylformamide are preheated to 50°. 16.5 g of isopropylbromide in 50 ml of dimethylformamide are added dropwise to the suspension over a 2 hour period, the reaction mixture further stirred for 3.5 hours at the same temperature, cooled and poured onto ice/water. The organic substance is extracted with benzene, the extracts washed with water, dried over sodium sulphate and evaporated and the title compound which remains converted to the fumarate form in isopropyl. M.P. 199°-200°.

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