Reaktion #54668

Reaktionsgleichung

p-menth-3-oyl chloride

Sodium bicarbonate

4-aminobut-2-yn-1-ol hydrochloride

→

N-(4-hydroxybut-2-ynyl)-p-menthane-3-carboxamide

Lösungsmittel

ether

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe ether layer separated
2. 2
   Trocknendried over MgSO4
3. 3
   SonstigeEvaporation of the ether

Vorschrift

Sodium bicarbonate (2.5 g.) and 4-aminobut-2-yn-1-ol hydrochloride (2.5 g.) were dissolved in water (60 ml.) and a solution of p-menth-3-oyl chloride in ether (100 ml.) added. The mixture was stirred vigorously for two hours and the ether layer separated and dried over MgSO4. Evaporation of the ether gave N-(4-hydroxybut-2-ynyl)-p-menthane-3-carboxamide as a very viscous liquid: b.p. 180°/0.1 mm.

Quelle