Reaktion #546487

ord-be2687985adb4295946fa79a95f481ac

Reaktionsgleichung

CCOC(=O)[C@H](Cc1ccc(OCCCBr)cc1)OC
(2S)-3-[4-(3-bromo-propoxy)-phenyl]-2-methoxy-propionic acid ethyl ester
Oc1cccc(-c2ccccc2)c1
biphenyl-3-ol
CO[C@@H](Cc1ccc(OCCCOc2ccccc2)cc1)C(=O)O
(2S)-2-methoxy-3-[4-(3-phenoxy-propoxy)-phenyl]-propionic acid
→
CO[C@@H](Cc1ccc(OCCCOc2cccc(-c3ccccc3)c2)cc1)C(=O)O
title compound
CO[C@@H](Cc1ccc(OCCCOc2cccc(-c3ccccc3)c2)cc1)C(=O)O
(2S)-3-{4-[3-(biphenyl-3-yloxy)-propoxy]-phenyl}-2-methoxy-propionic acid

Edukte

CCOC(=O)[C@H](Cc1ccc(OCCCBr)cc1)OC
(2S)-3-[4-(3-bromo-propoxy)-phenyl]-2-methoxy-propionic acid ethyl ester
Oc1cccc(-c2ccccc2)c1
biphenyl-3-ol
CO[C@@H](Cc1ccc(OCCCOc2ccccc2)cc1)C(=O)O
(2S)-2-methoxy-3-[4-(3-phenoxy-propoxy)-phenyl]-propionic acid

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigeto produce a colorless oil

Vorschrift

The title compound was prepared from (2S)-3-[4-(3-bromo-propoxy)-phenyl]-2-methoxy-propionic acid ethyl ester (Example 284, Step 2) and biphenyl-3-ol via the same procedure used for the preparation of (2S)-2-methoxy-3-[4-(3-phenoxy-propoxy)-phenyl]-propionic acid (Example 285, Step 1), to produce a colorless oil. MS (ES) for C25H25O5 [M+Na]+429.4.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07192982B2uspto-grants-2007_03