Reaktion #54594

Reaktionsgleichung

2,5-dimethoxytetrahydrofuran

sodium acetate

α-sulfo-α-aminoacetic acid hydrochloride

→

α-sulfo-α-(1-pyrryl) acetic acid

Lösungsmittel

acetic acid

ethylacetate

acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe solution is heated
2. 2
   Temperaturto reflux for 5 minutes
3. 3
   Temperaturrefluxed for an additional 2 minutes
4. 4
   Sonstigeevaporated
5. 5
   Sonstigeleaving a residue which
6. 6
   FiltrationThe ethyl acetate is filtered
7. 7
   Sonstigedried
8. 8
   Sonstigeevaporated

Vorschrift

To a solution of sodium acetate (0.1 mole) in about 300 ml of glacial acetic acid is added about 0.05 mole of α-sulfo-α-aminoacetic acid hydrochloride. The solution is heated to reflux for 5 minutes, 2,5-dimethoxytetrahydrofuran (1 equivalent based on α-sulfo-α-aminoacetic acid hydrochloride) is added as quickly as possible, and the solution refluxed for an additional 2 minutes. The acetic acid is flash evaporated leaving a residue which is taken up in ethylacetate. The ethyl acetate is filtered, dried and evaporated to give α-sulfo-α-(1-pyrryl) acetic acid.

Quelle