Reaktion #54592

Reaktionsgleichung

2-Aminopentanoic acid

sodium acetate

2.5-dimethoxytetrahydrofuran

→

2-(1-pyrryl)pentanoic acid

Lösungsmittel

acetic acid

acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThis solution is heated
2. 2
   Temperaturis then refluxed for 5 minutes
3. 3
   TemperaturThe mixture is refluxed for a further 2 minutes
4. 4
   Sonstigeevaporated
5. 5
   Waschenwashed with water
6. 6
   Sonstigedried
7. 7
   Sonstigethe solvent removed under vacuo

Vorschrift

2-Aminopentanoic acid (0.2 mole) is added to a solution of sodium acetate (0.2 mole) in about 300 ml of glacial acetic acid. This solution is heated to effect solution and is then refluxed for 5 minutes. To the refluxing solution is added (0.2 mole) 2.5-dimethoxytetrahydrofuran as quickly as possible. The mixture is refluxed for a further 2 minutes and the acetic acid is flash evaporated. The residue is taken up in ethyl acetate, washed with water, dried and the solvent removed under vacuo to give 2-(1-pyrryl)pentanoic acid.

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