Reaktion #54591

Reaktionsgleichung

water

Chloroform

potassium phthalimide

ethyl-2-bromopentanoate

→

ethyl α-phthalimidopentanoate

Lösungsmittel

DMF

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe phases are separated
2. 2
   Extraktionthe aqueous phase is extracted with chloroform
3. 3
   Extraktionextracted with 0.1 N sodium hydroxide and with water
4. 4
   TrocknenAfter drying over sodium sulfate
5. 5
   Sonstigethe chloroform is removed

Vorschrift

To a solution of potassium phthalimide (0.1 mole) in about 50 ml of dimethylformamide (DMF) is added 1 equivalent of ethyl-2-bromopentanoate. The temperature is maintained at about 60° C. for 10 minutes. Chloroform is added to the cooled DMF solution and the mixture is poured into water. The phases are separated and the aqueous phase is extracted with chloroform. The chloroform extracts are combined, extracted with 0.1 N sodium hydroxide and with water. After drying over sodium sulfate, the chloroform is removed to give ethyl α-phthalimidopentanoate.

Quelle