Reaktion #545887

Reaktionsgleichung

aluminum trichloride

dichloromethane

2,5-dichloro-2,5-dimethylhexane

phenol

→

title compound

Ausbeute 90.8%

5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthol

Ausbeute 90.8%

Lösungsmittel

methane dichloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooled
2. 2
   Extraktionextracted with ether (3×80 ml)
3. 3
   WaschenThe organic phase is washed with 10% NaHCO3 solution (2×150 ml)
4. 4
   Trocknendried over MgSO4
5. 5
   Sonstigeevaporated
6. 6
   Sonstigeto give a crude product, which
7. 7
   Sonstigeis crystallized from ethanol

Vorschrift

To a mixture of aluminum trichloride (3.0 g, 22.5 mmol), dichloromethane (50 ml) and 2,5-dichloro-2,5-dimethylhexane (15.0 g, 81.9 mmol) is added dropwise into a solution of phenol (7.7 g, 81.90 mmol) in 50 ml of methane dichloride, then the reaction mixture is heated for 4 hours at 35° C. After cooled, the reaction mixture is poured into ice (200 g) and extracted with ether (3×80 ml). The organic phase is washed with 10% NaHCO3 solution (2×150 ml), dried over MgSO4 and evaporated to give a crude product, which is crystallized from ethanol to give the title compound (15.20 g, 84%).

Quelle