Reaktion #54587

Reaktionsgleichung

3,3-bis(ethoxycarbonyl)-bicyclo[3.2.0]heptane

methanol water

→

bicyclo[3.2.0]heptane-3,3-dicarboxylic acid

Ausbeute 87.4%

Lösungsmittel

potassium hydroxide

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvents were removed in vacuo
2. 2
   workup.DISSOLUTIONthe residue dissolved in a minimum amount of water
3. 3
   Sonstigethe precipitated acid isolated by vacuum filtration

Vorschrift

A solution of 10.3 g of 3,3-bis(ethoxycarbonyl)-bicyclo[3.2.0]heptane in 68 ml of 16% potassium hydroxide in 1:1 methanol-water was refluxed for 16 hr under argon. The solvents were removed in vacuo and the residue dissolved in a minimum amount of water. The solution was acidified with concentrated hydrochloric acid and the precipitated acid isolated by vacuum filtration to yield 6.9 g of bicyclo[3.2.0]heptane-3,3-dicarboxylic acid as a white solid, mp 161°-170°.

Quelle