Reaktion #54545

Reaktionsgleichung

iodine

ethyl acetate

1-[2-(dimethylamino)-ethyl]-1,4-cyclohexadiene

iodine

acetic acid

→

trans-4-[2-(dimethylamino)-ethyl]-4-cyclohexene-1,2-diol

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.DISSOLUTIONdissolves
2. 2
   Temperaturis then heated for two hours at 95°
3. 3
   TemperaturThe reaction solution is cooled
4. 4
   Filtrationfiltered
5. 5
   Sonstigeevaporated in vacuo
6. 6
   Sonstigeto give an oil
7. 7
   Waschenwashed with aqueous sodium bicarbonate solution
8. 8
   TrocknenThe organic phase is dried (MgSO4)
9. 9
   Sonstigeevaporated to an oil
10. 10
    workup.ADDITIONtreated with HCl in isoproanol
11. 11
    SonstigeThe resulting crude solid is removed by filtration
12. 12
    Sonstigerecrystallized from acetonitrile-ether

Vorschrift

A solution of 45 g. (0.3 moles) of 1-[2-(dimethylamino)-ethyl]-1,4-cyclohexadiene from Example 3(a) in 1.5 l. of dry glacial acetic acid is treated with 100 g. of silver acetate and 75 g. of iodine. The mixture is stirred until most of the iodine dissolves and is then heated for two hours at 95°. The reaction solution is cooled, filtered and evaporated in vacuo to give an oil. The oil is taken up in ethyl acetate and washed with aqueous sodium bicarbonate solution. The organic phase is dried (MgSO4) and evaporated to an oil. The oil is taken up in ethyl acetate and treated with HCl in isoproanol. The resulting crude solid is removed by filtration and recrystallized from acetonitrile-ether to yield dl-trans-4-[2-(dimethylamino)-ethyl]-4-cyclohexene-1,2-diol, diacetate ester, hydrochloride salt.

Quelle