Reaktion #54538

ord-2a2510b7c17045cab93fdfe78cb15e3b

Reaktionsgleichung

CN(C)[C@@H]1CCCC[C@H]1N
trans-2-(dimethylamino)cyclohexylamine
CC(=O)Cl
acetyl chloride
O=C([O-])[O-].[K+].[K+]
K2CO3
→
CC(=O)N[C@@H]1CCCC[C@H]1N(C)C
amide
CC(=O)N[C@@H]1CCCC[C@H]1N(C)C
trans-N-[2-(Dimethylamino)-cyclohexyl]-acetamide

Edukte

CN(C)[C@@H]1CCCC[C@H]1N
trans-2-(dimethylamino)cyclohexylamine
CC(=O)Cl
acetyl chloride
O=C([O-])[O-].[K+].[K+]
K2CO3

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Extraktionextracted well with ether
  2. 2
    SonstigeThe resulting oil was crystallized from ether-petroleum ether (30°-60°)

Vorschrift

This amide was prepared by general procedure A from trans-2-(dimethylamino)cyclohexylamine and acetyl chloride. In the work up the aqueous layer was salted out with solid K2CO3, and extracted well with ether. The resulting oil was crystallized from ether-petroleum ether (30°-60°) to give colorless rods of the sub-titled amide, 79% yield, m.p. 86°-87.5° raised to 88°-89° on recrystallization. ir NH 3280, 3080; N-alkyl 2770; C=O 1660, 1640; amide II 1565. nmr in CDCl3 and 100 MHz was in accord. Mass spectrum M+ 184.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04148914uspto-grants-1979_04