Reaktion #54536

Reaktionsgleichung

trans 2-(dimethylamino)cyclohexyl-amine

ethyl formate

→

trans-N-[2-(Dimethylamino)-cyclohexyl]-formamide

Ausbeute 85.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeevaporated
2. 2
   workup.DISTILLATIONThe titled product (A) was distilled at 0.1 mm, b.p. 104°, 5.2 g

Vorschrift

A solution of the trans 2-(dimethylamino)cyclohexyl-amine prepared as in Procedure VIII (5.12 g.; 0.036 mole) and 100 ml. of ethyl formate (distilled over K2CO3) was refluxed for 17 hours and evaporated. The titled product (A) was distilled at 0.1 mm, b.p. 104°, 5.2 g. (85% yield). ir NH 3280, 3040; CH 2930, 2860; N-alkyl 2770; C=O 1670; amide II 1540; other 1450, 1385. nmr in CDCl3 (100 MHz) was in accord. Mass spectrum M+ 170.

Quelle