Reaktion #54528

Reaktionsgleichung

EtOH

dimethylamine

→

trans-N,N-Dimethyl-1,2-cyclohexanediamine

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationfiltered through Celite
2. 2
   Sonstigeevaporated in vacuo at 45°
3. 3
   TemperaturThe residue was cooled in ice
4. 4
   ExtraktionThe resulting thick suspension was extracted with ether (5×200 ml)
5. 5
   Extraktionthe ether extract
6. 6
   Trocknenwas dried (MgSO4)
7. 7
   Sonstigeevaporated through a 9" Vigreux
8. 8
   workup.DISTILLATIONThe residue was distilled at 13 mm
9. 9
   Sonstigeto give 32.5 g

Vorschrift

A solution of the benzylamino compound was hydrogenated in two batches each containing 30.5 g. (0.131 mole), 175 ml. EtOH, 3.5 g Pd--C and 56.5 g. (0.394 mole) of 70% HClO4, at initial pressure of 51.5 p.s.i. for 19 hours. The two batches were combined, filtered through Celite and evaporated in vacuo at 45°. The residue was cooled in ice, basified with 40% KOH to pH 11. The resulting thick suspension was extracted with ether (5×200 ml), the ether extract was dried (MgSO4) and evaporated through a 9" Vigreux. The residue was distilled at 13 mm to give 32.5 g. (87% yield), b.p. 77°-78.5°. Vpc 100% at 3.8 mm. ir and nmr was identical to those of the sample prepared by the reaction of 7-azabicyclo[3.1.0]heptane with dimethylamine.

Quelle