Reaktion #54490

Reaktionsgleichung

1-phenyl-2-(1-piperazinyl)-indole-3-carboxylic acid-4-methyl-piperazide

chloroformic acid-2-methyl-2-propenyl ester

sodium carbonate

→

2-[4-(2-Methyl-2-propenyl)oxycarbonyl-1-piperazinyl]-1-phenylindole-3-carboxylic acid-4-methyl-piperazide

Ausbeute 94.0%

Lösungsmittel

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe crystalline residue of the organic phase was triturated with ether
2. 2
   Filtrationsuction-filtered
3. 3
   Waschenwashed with ether

Vorschrift

Reaction in analogy to Example 60 from 1-phenyl-2-(1-piperazinyl)-indole-3-carboxylic acid-4-methyl-piperazide and chloroformic acid-2-methyl-2-propenyl ester. After working up with methylene chloride and heated sodium carbonate solution, the crystalline residue of the organic phase was triturated with ether, suction-filtered and washed with ether. Melting point: 141°-143° C., yield: 94% of the theory.

Quelle