Reaktion #544754

Reaktionsgleichung

1-(2-chloro-4-nitrophenyl)-4-methylpiperazine

tin (II) chloride

→

title compound

Ausbeute 95.0%

3–Chloro-4-(4-methylpiperazin-1-yl)aniline

Ausbeute 95.0%

Lösungsmittel

HCl

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationthe solids were collected by filtration
2. 2
   workup.DISSOLUTIONdissolved in aqueous 1 N NaOH (300 mL)
3. 3
   ExtraktionThe aqueous solution was extracted with ethyl acetate (3×50 mL)
4. 4
   WaschenThe combined organic layers were washed with brine
5. 5
   Trocknendried over anhydrous magnesium sulfate
6. 6
   Filtrationfiltered
7. 7
   Sonstigeevaporated

Vorschrift

To a stirred solution of 1-(2-chloro-4-nitrophenyl)-4-methylpiperazine (2.43 g, 9.5 mmol) in 2N HCl (35 mL) at RT was added tin (II) chloride (7.2 g, 38 mmol). After 1 h, the solids were collected by filtration and dissolved in aqueous 1 N NaOH (300 mL). The aqueous solution was extracted with ethyl acetate (3×50 mL). The combined organic layers were washed with brine, dried over anhydrous magnesium sulfate, filtered, and evaporated to afford the title compound (2.02 g, 95%).

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