Reaktion #5445

Reaktionsgleichung

product

8-Methoxy-2-(2-aminoethyl)-1,2,3,3a,8,8a-hexahydroindeno[1,2-c]pyrrole

p-fluorobenzoyl chloride

→

desired product

8-Methoxy-2-(2-(4-fluorobenzamido)ethyl)-1,2,3,3a,8,8a-hexahydroindeno[1,2-c]pyrrole hydrochloride

Lösungsmittel

triethyl amine

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe reaction was quenched in 5% NaHCO3
2. 2
   Extraktionextracted with ethyl acetate
3. 3
   TrocknenThe organic extracts were dried (Na2SO4)
4. 4
   Sonstigeevaporated
5. 5
   workup.DISSOLUTIONthe product was dissolved in ether
6. 6
   workup.ADDITIONtreated with ethereal HCl
7. 7
   Sonstigeevaporated to dryness
8. 8
   SonstigeThe resulting product was recrystallized from ethyl acetate and ether

Vorschrift

The product from Example 17 (0.95 g) was dissolved in 50 ml methylene chloride and 1.5 ml triethyl amine. The solution was cooled to -20° C. and 0.59 ml p-fluorobenzoyl chloride was added. After 30 min, the reaction was quenched in 5% NaHCO3 and extracted with ethyl acetate. The organic extracts were dried (Na2SO4), evaporated, and the product was dissolved in ether and treated with ethereal HCl and then evaporated to dryness. The resulting product was recrystallized from ethyl acetate and ether to yield 0.772 g of the desired product as a white solid, mp: 197°-8° C. NMR (d6DMSO) δ2.60-3.10 (m, 3H), 3.00-3.50 (m, 4H), 3.59 (m, 2H), 3.78 (s, 3H), 3.82-4.22 (m, 3H), 6.83 (d, 1H), 6.87 (d, 1H), 7.23 (t, 1H), 7.34 (m, 2 H), 8.00 (m, 2H).

Quelle