Reaktion #543708

ord-3ed5a21985eb42eb9014494fe02b7a30

Reaktionsgleichung

Cc1csc(C(=NO)C2CCN(C(=O)OC(C)(C)C)CC2)c1Br
29b
Cc1csc(C(=NO)C2CCN(C(=O)OC(C)(C)C)CC2)c1Br
4-[l-(3-bromo-4-methyl-thiophen-2-yl)-1-hydroxyimino-methyl]-piperidine-1-carboxylic acid tert-butyl ester
Cc1cc(Br)c(C(=O)C2CCN(C(=O)OC(C)(C)C)CC2)s1
4-[1-(3-Bromo-5-methyl-thiophen-2-yl)-methanoyl]-piperidine-1-carboxylic acid tert-butyl ester
→
Cc1cc(Br)c(C(=NO)C2CCN(C(=O)OC(C)(C)C)CC2)s1
4-[1-(3-bromo-5-methyl-thiophen-2-yl)-1-hydroxyimino-methyl]-piperidine-1-carboxylic acid tert-butyl ester

Edukte

Cc1csc(C(=NO)C2CCN(C(=O)OC(C)(C)C)CC2)c1Br
29b
Cc1csc(C(=NO)C2CCN(C(=O)OC(C)(C)C)CC2)c1Br
4-[l-(3-bromo-4-methyl-thiophen-2-yl)-1-hydroxyimino-methyl]-piperidine-1-carboxylic acid tert-butyl ester
Cc1cc(Br)c(C(=O)C2CCN(C(=O)OC(C)(C)C)CC2)s1
4-[1-(3-Bromo-5-methyl-thiophen-2-yl)-methanoyl]-piperidine-1-carboxylic acid tert-butyl ester
—
II

Reagenzien

Keine

Reaktionsbedingungen

Temperatur
70°CELSIUS
Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Prepared essentially as 29b except that 4-[1-(3-Bromo-5-methyl-thiophen-2-yl)-methanoyl]-piperidine-1-carboxylic acid tert-butyl ester is used as the starting material and the reaction mixture was stirred at 70° C. for 6 hours. LC/MS (ESI), m/e 347 (M-56) and 403 (MH+), retention time 2.03 minutes. Condition II.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07186724B2uspto-grants-2007_03